T cell fate and clonality inference from single cell transcriptomes

The enormous sequence diversity within T cell receptor (TCR) repertoires allows specific TCR sequences to be used as lineage markers for T cells that derive from a common progenitor. We have developed a computational method, called TraCeR, to reconstruct full-length, paired TCR sequences from T lymp...

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Udgivet i:Nat Methods
Main Authors: Stubbington, Michael J.T., Lönnberg, Tapio, Proserpio, Valentina, Clare, Simon, Speak, Anneliese O., Dougan, Gordon, Teichmann, Sarah A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835021/
https://ncbi.nlm.nih.gov/pubmed/26950746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3800
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