Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

[Image: see text] The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment screening hit scaffold using st...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Cross, Jason B., Zhang, Jing, Yang, Qingyi, Mesleh, Michael F., Romero, Jan Antoinette C., Wang, Bin, Bevan, Doug, Poutsiaka, Katherine M., Epie, Felix, Moy, Terence, Daniel, Anu, Shotwell, Joseph, Chamberlain, Brian, Carter, Nicole, Andersen, Ole, Barker, John, Ryan, M. Dominic, Metcalf, Chester A., Silverman, Jared, Nguyen, Kien, Lippa, Blaise, Dolle, Roland E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834655/
https://ncbi.nlm.nih.gov/pubmed/27096044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00368
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