Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

[Image: see text] The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment screening hit scaffold using st...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:ACS Med Chem Lett
Main Authors: Cross, Jason B., Zhang, Jing, Yang, Qingyi, Mesleh, Michael F., Romero, Jan Antoinette C., Wang, Bin, Bevan, Doug, Poutsiaka, Katherine M., Epie, Felix, Moy, Terence, Daniel, Anu, Shotwell, Joseph, Chamberlain, Brian, Carter, Nicole, Andersen, Ole, Barker, John, Ryan, M. Dominic, Metcalf, Chester A., Silverman, Jared, Nguyen, Kien, Lippa, Blaise, Dolle, Roland E.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2016
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834655/
https://ncbi.nlm.nih.gov/pubmed/27096044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00368
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים