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Direct observation of helicase–topoisomerase coupling within reverse gyrase

Reverse gyrases (RGs) are the only topoisomerases capable of generating positive supercoils in DNA. Members of the type IA family, they do so by generating a single-strand break in substrate DNA and then manipulating the two single strands to generate positive topology. Here, we use single-molecule...

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Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Yang, Xi, Garnier, Florence, Débat, Hélène, Strick, Terence R., Nadal, Marc
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245102/
https://ncbi.nlm.nih.gov/pubmed/32371489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921848117
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