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Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations

[Image: see text] New pseudotrisaccharide derivatives of aminoglycosides that exploit additional interaction on the shallow groove face of the decoding-site rRNA of eukaryotic ribosome were designed, synthesized and biologically evaluated. Novel lead structures (6 and 7 with an additional 7′-OH), ex...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Sabbavarapu, Narayana Murthy, Shavit, Michal, Degani, Yarden, Smolkin, Boris, Belakhov, Valery, Baasov, Timor
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834649/
https://ncbi.nlm.nih.gov/pubmed/27096052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00006
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