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Triazolylthioacetamide: A Valid Scaffold for the Development of New Delhi Metallo-β-Lactmase-1 (NDM-1) Inhibitors

[Image: see text] The metallo-β-lactamases (MβLs) cleave the β-lactam ring of β-lactam antibiotics, conferring resistance against these drugs to bacteria. Twenty-four triazolylthioacetamides were prepared and evaluated as inhibitors of representatives of the three subclasses of MβLs. All these compo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Zhai, Le, Zhang, Yi-Lin, Kang, Joon S., Oelschlaeger, Peter, Xiao, Lin, Nie, Sha-Sha, Yang, Ke-Wu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2016
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834647/
https://ncbi.nlm.nih.gov/pubmed/27096051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00495
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