Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors

[Image: see text] The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple myeloma. Starting from a moderately potent quinoxaline-dihydropyrrolopiperidinone lead, we recognize...

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Julkaisussa:ACS Med Chem Lett
Päätekijät: Cee, Victor J., Chavez, Frank, Herberich, Bradley, Lanman, Brian A., Pettus, Liping H., Reed, Anthony B., Wu, Bin, Wurz, Ryan P., Andrews, Kristin L., Chen, Jie, Hickman, Dean, Laszlo, Jimmy, Lee, Matthew R., Guerrero, Nadia, Mattson, Bethany K., Nguyen, Yen, Mohr, Christopher, Rex, Karen, Sastri, Christine E., Wang, Paul, Wu, Qiong, Wu, Tian, Xu, Yang, Zhou, Yihong, Winston, Jeffrey T., Lipford, J. Russell, Tasker, Andrew S., Wang, Hui-Ling
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2016
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834646/
https://ncbi.nlm.nih.gov/pubmed/27096050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00403
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