Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors

[Image: see text] The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple myeloma. Starting from a moderately potent quinoxaline-dihydropyrrolopiperidinone lead, we recognize...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cee, Victor J., Chavez, Frank, Herberich, Bradley, Lanman, Brian A., Pettus, Liping H., Reed, Anthony B., Wu, Bin, Wurz, Ryan P., Andrews, Kristin L., Chen, Jie, Hickman, Dean, Laszlo, Jimmy, Lee, Matthew R., Guerrero, Nadia, Mattson, Bethany K., Nguyen, Yen, Mohr, Christopher, Rex, Karen, Sastri, Christine E., Wang, Paul, Wu, Qiong, Wu, Tian, Xu, Yang, Zhou, Yihong, Winston, Jeffrey T., Lipford, J. Russell, Tasker, Andrew S., Wang, Hui-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834646/
https://ncbi.nlm.nih.gov/pubmed/27096050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00403
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