Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

AIMS: Use of the anti‐tumour antibiotic actinomycin D is associated with development of hepatotoxicity, particularly in young children. A paucity of actinomycin D pharmacokinetic data make it challenging to develop a sound rationale for defining dosing regimens in younger patients. The study aim was...

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Publicat a:Br J Clin Pharmacol
Autors principals: Walsh, Christopher, Bonner, Jennifer J., Johnson, Trevor N., Neuhoff, Sibylle, Ghazaly, Essam A., Gribben, John G., Boddy, Alan V., Veal, Gareth J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Paediatric Clinical Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834588/
https://ncbi.nlm.nih.gov/pubmed/26727248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12878
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