Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

Actinomycin D plays a key role in the successful treatment of Wilms tumour. However, associated liver toxicities remain a drawback to potentially curative treatment. We have used MDCKII cells over-expressing ABCB1, ABCC1, ABCC2 and ABCG2, alongside knockout mouse models to characterise actinomycin D...

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Bibliographic Details
Main Authors: Hill, Christopher R., Jamieson, David, Thomas, Huw D., Brown, Colin D.A., Boddy, Alan V., Veal, Gareth J.
Format: Artigo
Language:Inglês
Published: Elsevier Science 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545186/
https://ncbi.nlm.nih.gov/pubmed/23063411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.10.004
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