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The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain
Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the blood-brain barrier (BBB) efflux transporters ABCG2 and ABCC4 influence the required high-dose therapy is unknown. To evaluate their role, we used four mouse strains, C57BL/6 (wild-type; WT...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965903/ https://ncbi.nlm.nih.gov/pubmed/24464805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.055228 |
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