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The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain
Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the blood-brain barrier (BBB) efflux transporters ABCG2 and ABCC4 influence the required high-dose therapy is unknown. To evaluate their role, we used four mouse strains, C57BL/6 (wild-type; WT...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965903/ https://ncbi.nlm.nih.gov/pubmed/24464805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.055228 |
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