The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats

E-52862 is a selective σ(1)R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a potential first-in-class analgesic. Here, we investigated the effect of single and repeated administration of E-52862 on different pain-related behaviours in several neuropathi...

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Vydáno v:Sci Rep
Hlavní autoři: Gris, Georgia, Portillo-Salido, Enrique, Aubel, Bertrand, Darbaky, Yassine, Deseure, Kristof, Vela, José Miguel, Merlos, Manuel, Zamanillo, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834548/
https://ncbi.nlm.nih.gov/pubmed/27087602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24591
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