Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

BACKGROUND AND PURPOSE: The sigma-1 (σ(1)) receptor is a ligand-regulated molecular chaperone that has been involved in pain, but there is limited understanding of the actions associated with its pharmacological modulation. Indeed, the selectivity and pharmacological properties of σ(1) receptor liga...

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Dettagli Bibliografici
Autori principali: Romero, L, Zamanillo, D, Nadal, X, Sánchez-Arroyos, R, Rivera-Arconada, I, Dordal, A, Montero, A, Muro, A, Bura, A, Segalés, C, Laloya, M, Hernández, E, Portillo-Salido, E, Escriche, M, Codony, X, Encina, G, Burgueño, J, Merlos, M, Baeyens, JM, Giraldo, J, López-García, JA, Maldonado, R, Plata-Salamán, CR, Vela, JM
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2012
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448894/
https://ncbi.nlm.nih.gov/pubmed/22404321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01942.x
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