Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

BACKGROUND AND PURPOSE: The sigma-1 (σ(1)) receptor is a ligand-regulated molecular chaperone that has been involved in pain, but there is limited understanding of the actions associated with its pharmacological modulation. Indeed, the selectivity and pharmacological properties of σ(1) receptor liga...

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Detalhes bibliográficos
Main Authors: Romero, L, Zamanillo, D, Nadal, X, Sánchez-Arroyos, R, Rivera-Arconada, I, Dordal, A, Montero, A, Muro, A, Bura, A, Segalés, C, Laloya, M, Hernández, E, Portillo-Salido, E, Escriche, M, Codony, X, Encina, G, Burgueño, J, Merlos, M, Baeyens, JM, Giraldo, J, López-García, JA, Maldonado, R, Plata-Salamán, CR, Vela, JM
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448894/
https://ncbi.nlm.nih.gov/pubmed/22404321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01942.x
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