Translational Pharmacokinetic‐Pharmacodynamic Modeling and Simulation: Optimizing 5‐Fluorouracil Dosing in Children With Pediatric Ependymoma

We previously investigated novel therapies for pediatric ependymoma and found 5‐fluorouracil (5‐FU) i.v. bolus increased survival in a representative mouse model. However, without a quantitative framework to derive clinical dosing recommendations, we devised a translational pharmacokinetic‐pharmacod...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Daryani, VM, Patel, YT, Tagen, M, Turner, DC, Carcaboso, AM, Atkinson, JM, Gajjar, A, Gilbertson, RJ, Wright, KD, Stewart, CF
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834132/
https://ncbi.nlm.nih.gov/pubmed/27104090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12075
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi