Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and is overexpressed in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer progression by generating severe combined immune deficient (SCID) mice deficient in integrin α11 (α11) expression...

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Publicat a:Oncogene
Autors principals: Navab, R, Strumpf, D, To, C, Pasko, E, Kim, K S, Park, C J, Hai, J, Liu, J, Jonkman, J, Barczyk, M, Bandarchi, B, Wang, Y H, Venkat, K, Ibrahimov, E, Pham, N-A, Ng, C, Radulovich, N, Zhu, C-Q, Pintilie, M, Wang, D, Lu, A, Jurisica, I, Walker, G C, Gullberg, D, Tsao, M-S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833874/
https://ncbi.nlm.nih.gov/pubmed/26148229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.254
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