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E-type cyclins modulate telomere integrity in mammalian male meiosis
We have shown that E-type cyclins are key regulators of mammalian male meiosis. Depletion of cyclin E2 reduced fertility in male mice due to meiotic defects, involving abnormal pairing and synapsis, unrepaired DNA, and loss of telomere structure. These defects were exacerbated by additional loss of...
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| Publicado no: | Chromosoma |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833587/ https://ncbi.nlm.nih.gov/pubmed/26712234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00412-015-0564-3 |
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