Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.

Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility. To elucidate the role of E-type cyclins during spermatogenesis, we characterized their expression patterns and produced additional deletions of C...

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Autores principales: Laetitia Martinerie, Marcia Manterola, Sanny S W Chung, Sunil K Panigrahi, Melissa Weisbach, Ana Vasileva, Yan Geng, Peter Sicinski, Debra J Wolgemuth
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2014-02-01
Colección:PLoS Genetics
Acceso en línea:http://europepmc.org/articles/PMC3937215?pdf=render
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