TETRAHYDROPROTOBERBERINE ALKALOIDS WITH DOPAMINE AND σ RECEPTOR AFFINITY

Two series of analogues of the tetrahydroprotoberberine (THPB) alkaloid (±)-stepholidine that a) contain various alkoxy substituents at the C10 position and, b) were de-rigidified with respect to (±)-stepholidine, were synthesized and evaluated for affinity at dopamine and σ receptors in order to ev...

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發表在:Bioorg Med Chem
Main Authors: Gadhiya, Satishkumar, Madapa, Sudharshan, Kurtzman, Thomas, Alberts, Ian L., Ramsey, Steven, Pillarsetty, Nagavara-Kishore, Kalidindi, Teja, Harding, Wayne W.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833520/
https://ncbi.nlm.nih.gov/pubmed/27032890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.03.037
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