New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif

[Image: see text] A series of analogues featuring a 6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol unit as the arylamine “head” group of a classical D3 antagonist core structure were synthesized and evaluated for affinity at dopamine D1, D2, and D3 receptors (D1R, D2R, D3R). The compounds generally di...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Gadhiya, Satishkumar, Cordone, Pierpaolo, Pal, Rajat K., Gallicchio, Emilio, Wickstrom, Lauren, Kurtzman, Tom, Ramsey, Steven, Harding, Wayne W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187407/
https://ncbi.nlm.nih.gov/pubmed/30344905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00229
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