Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis

The genetic mechanisms underlying the poor prognosis of esophageal squamous cell carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in ESCC from sequencing 10 whole-genome and 57 whole-exome matched tumor-normal sample pairs. Among the identified genes, we characterize...

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Publicado en:Am J Hum Genet
Autores principales: Qin, Hai-De, Liao, Xiao-Yu, Chen, Yuan-Bin, Huang, Shao-Yi, Xue, Wen-Qiong, Li, Fang-Fang, Ge, Xiao-Song, Liu, De-Qing, Cai, Qiuyin, Long, Jirong, Li, Xi-Zhao, Hu, Ye-Zhu, Zhang, Shao-Dan, Zhang, Lan-Jun, Lehrman, Benjamin, Scott, Alan F., Lin, Dongxin, Zeng, Yi-Xin, Shugart, Yin Yao, Jia, Wei-Hua
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833434/
https://ncbi.nlm.nih.gov/pubmed/27058444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.02.021
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