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OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not responded to other treatment. Here we report that OTSSP167 abrogates the mitotic checkpoint at concentration...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833387/ https://ncbi.nlm.nih.gov/pubmed/27082996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153518 |
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