Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity in multiple myeloma bone disease

Multiple myeloma bone disease is characterized by an uncoupling of bone remodeling in the multiple myeloma microenvironment, resulting in the development of lytic bone lesions. Most myeloma patients suffer from these bone lesions, which not only cause morbidity but also negatively impact survival. T...

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Vydáno v:Haematologica
Hlavní autoři: Muller, Joséphine, Bolomsky, Arnold, Dubois, Sophie, Duray, Elodie, Stangelberger, Kathrin, Plougonven, Erwan, Lejeune, Margaux, Léonard, Angélique, Marty, Caroline, Hempel, Ute, Baron, Frédéric, Beguin, Yves, Cohen-Solal, Martine, Ludwig, Heinz, Heusschen, Roy, Caers, Jo
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068043/
https://ncbi.nlm.nih.gov/pubmed/29748441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.185397
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