Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity in multiple myeloma bone disease

Multiple myeloma bone disease is characterized by an uncoupling of bone remodeling in the multiple myeloma microenvironment, resulting in the development of lytic bone lesions. Most myeloma patients suffer from these bone lesions, which not only cause morbidity but also negatively impact survival. T...

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Pubblicato in:Haematologica
Autori principali: Muller, Joséphine, Bolomsky, Arnold, Dubois, Sophie, Duray, Elodie, Stangelberger, Kathrin, Plougonven, Erwan, Lejeune, Margaux, Léonard, Angélique, Marty, Caroline, Hempel, Ute, Baron, Frédéric, Beguin, Yves, Cohen-Solal, Martine, Ludwig, Heinz, Heusschen, Roy, Caers, Jo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068043/
https://ncbi.nlm.nih.gov/pubmed/29748441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.185397
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