Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified functional partner iglr-2, are glucose intolerant...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Svensk, Emma, Devkota, Ranjan, Ståhlman, Marcus, Ranji, Parmida, Rauthan, Manish, Magnusson, Fredrik, Hammarsten, Sofia, Johansson, Maja, Borén, Jan, Pilon, Marc
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833288/
https://ncbi.nlm.nih.gov/pubmed/27082444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005982
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