Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified functional partner iglr-2, are glucose intolerant...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Svensk, Emma, Devkota, Ranjan, Ståhlman, Marcus, Ranji, Parmida, Rauthan, Manish, Magnusson, Fredrik, Hammarsten, Sofia, Johansson, Maja, Borén, Jan, Pilon, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833288/
https://ncbi.nlm.nih.gov/pubmed/27082444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005982
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