Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation

Bacterial pathogens must acquire host iron for survival and colonization. Because free iron is restricted in the host, numerous pathogens have evolved to overcome this limitation by using a family of monooxygenases that mediate the oxidative cleavage of heme into biliverdin, carbon monoxide, and iro...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Matsui, Toshitaka, Nambu, Shusuke, Goulding, Celia W., Takahashi, Satoshi, Fujii, Hiroshi, Ikeda-Saito, Masao
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833273/
https://ncbi.nlm.nih.gov/pubmed/27006503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523333113
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