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Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT

The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been found in and p...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zhu, Jianjian, Kwan, Kin Ming, Mackem, Susan
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833266/
https://ncbi.nlm.nih.gov/pubmed/27006501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601252113
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