Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs) to account for population structure and relatedness, for both continuous and binary traits. Motivated by the failure of LMMs to control type I errors in a GWAS of asthma, a binary trait, we show that LMMs are gener...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Chen, Han, Wang, Chaolong, Conomos, Matthew P., Stilp, Adrienne M., Li, Zilin, Sofer, Tamar, Szpiro, Adam A., Chen, Wei, Brehm, John M., Celedón, Juan C., Redline, Susan, Papanicolaou, George J., Thornton, Timothy A., Laurie, Cathy C., Rice, Kenneth, Lin, Xihong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833218/
https://ncbi.nlm.nih.gov/pubmed/27018471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.02.012
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