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4β‐hydroxycholesterol correlates with dose but not steady‐state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation?

AIM: 4β‐hydroxycholesterol (4βOHC) is an endogenous CYP3A(4) biomarker, which is elevated by use of the CYP3A4 inducer carbamazepine. Our aim was to compare to what extent serum concentration of 4βOHC correlates with dose (presystemic exposure) and steady‐state concentration (systemic exposure) of c...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Gjestad, Caroline, Huynh, Duy Khanh, Haslemo, Tore, Molden, Espen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833147/
https://ncbi.nlm.nih.gov/pubmed/26574235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12833
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