Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

Mechanisms involved in drug-induced cholestasis in humans remain poorly understood. Although cyclosporine A (CsA) and tacrolimus (FK506) share similar immunosuppressive properties, only CsA is known to cause dose-dependent cholestasis. Here, we have investigated the mechanisms implicated in early ch...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Sharanek, Ahmad, Azzi, Pamela Bachour-El, Al-Attrache, Houssein, Savary, Camille C., Humbert, Lydie, Rainteau, Dominique, Guguen-Guillouzo, Christiane, Guillouzo, André
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Cyclosporine and Bile Function
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833109/
https://ncbi.nlm.nih.gov/pubmed/24973091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu122
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