Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy

Juvenile myelomonocytic leukemia (JMML) is an aggressive pediatric mixed myelodysplastic/myeloproliferative neoplasm (MDS/MPN). JMML leukemogenesis is linked to a hyperactivated RAS pathway, with driver mutations in the KRAS, NRAS, NF1, PTPN11, or CBL genes. Previous murine models demonstrated how t...

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Pubblicato in:Blood
Autori principali: Liu, Y. Lucy, Yan, Yan, Webster, Cody, Shao, Lijian, Lensing, Shelly Y., Ni, Hongyu, Feng, Wei, Colorado, Natalia, Pathak, Rupak, Xiang, Zhifu, Hauer-Jensen, Martin, Li, Shaoguang, Zhou, Daohong, Emanuel, Peter D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832508/
https://ncbi.nlm.nih.gov/pubmed/26764354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646216
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