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Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods

Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stat Med
Prif Awduron: Burgess, Stephen, Dudbridge, Frank, Thompson, Simon G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832315/
https://ncbi.nlm.nih.gov/pubmed/26661904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6835
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