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Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods

Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Burgess, Stephen, Dudbridge, Frank, Thompson, Simon G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832315/
https://ncbi.nlm.nih.gov/pubmed/26661904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6835
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