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Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods

Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which...

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Vydáno v:Stat Med
Hlavní autoři: Burgess, Stephen, Dudbridge, Frank, Thompson, Simon G.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832315/
https://ncbi.nlm.nih.gov/pubmed/26661904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6835
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