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Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis
The transcriptional regulator PhoP is an essential virulence factor in Mycobacterium tuberculosis, and it presents a target for the development of new anti-tuberculosis drugs and attenuated tuberculosis vaccine strains. PhoP binds to DNA as a highly cooperative dimer by recognizing direct repeats of...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4832192/ https://ncbi.nlm.nih.gov/pubmed/27079268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24442 |
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