FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed si...

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Publicat a:Nat Commun
Autors principals: Bosma, Madeleen, Gerling, Marco, Pasto, Jenny, Georgiadi, Anastasia, Graham, Evan, Shilkova, Olga, Iwata, Yasunori, Almer, Sven, Söderman, Jan, Toftgård, Rune, Wermeling, Fredrik, Boström, Elisabeth Almer, Boström, Pontus Almer
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832079/
https://ncbi.nlm.nih.gov/pubmed/27066907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11314
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