FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed si...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bosma, Madeleen, Gerling, Marco, Pasto, Jenny, Georgiadi, Anastasia, Graham, Evan, Shilkova, Olga, Iwata, Yasunori, Almer, Sven, Söderman, Jan, Toftgård, Rune, Wermeling, Fredrik, Boström, Elisabeth Almer, Boström, Pontus Almer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832079/
https://ncbi.nlm.nih.gov/pubmed/27066907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11314
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