FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed si...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bosma, Madeleen, Gerling, Marco, Pasto, Jenny, Georgiadi, Anastasia, Graham, Evan, Shilkova, Olga, Iwata, Yasunori, Almer, Sven, Söderman, Jan, Toftgård, Rune, Wermeling, Fredrik, Boström, Elisabeth Almer, Boström, Pontus Almer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832079/
https://ncbi.nlm.nih.gov/pubmed/27066907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11314
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