FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed si...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Bosma, Madeleen, Gerling, Marco, Pasto, Jenny, Georgiadi, Anastasia, Graham, Evan, Shilkova, Olga, Iwata, Yasunori, Almer, Sven, Söderman, Jan, Toftgård, Rune, Wermeling, Fredrik, Boström, Elisabeth Almer, Boström, Pontus Almer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832079/
https://ncbi.nlm.nih.gov/pubmed/27066907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11314
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