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Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable using CHRM1 allosteric modulators. Allosteric modulators have been shown to change the activity of CHRMs using cloned human CHRMs and CHRM knockout mice but not human CNS, a...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Dean, Brian, Hopper, Shaun, Conn, P Jeffrey, Scarr, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832025/
https://ncbi.nlm.nih.gov/pubmed/26511338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.330
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