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Ups and Downs of Poised RNA Polymerase II in B-Cells

Recent genome-wide analyses have uncovered a high accumulation of RNA polymerase II (Pol II) at the 5′ end of genes. This elevated Pol II presence at promoters, referred to here as Poll II poising, is mainly (but not exclusively) attributed to temporal pausing of transcription during early elongatio...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Dao, Phuong, Wojtowicz, Damian, Nelson, Steevenson, Levens, David, Przytycka, Teresa M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831825/
https://ncbi.nlm.nih.gov/pubmed/27078128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004821
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