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Structural and functional properties of prefibrillar α-synuclein oligomers

The deposition of fibrillar alpha-synuclein (α-syn) within inclusions (Lewy bodies and Lewy neurites) in neurons and glial cells is a hallmark of synucleinopathies. α-syn populates a variety of assemblies ranging from prefibrillar oligomeric species to fibrils whose specific contribution to neurodeg...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Pieri, Laura, Madiona, Karine, Melki, Ronald
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830946/
https://ncbi.nlm.nih.gov/pubmed/27075649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24526
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