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Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca(2+)-induced Mitochondrial Dysfunction
α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the pathogenesis of Parkinson disease (PD). Although recent studies have suggested that mitochondrial association of αSyn may disrupt mitochondrial function, it is unclear what aggregation state of αSyn is most damaging...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4118111/ https://ncbi.nlm.nih.gov/pubmed/24942732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545749 |
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