Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca(2+)-induced Mitochondrial Dysfunction

α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the pathogenesis of Parkinson disease (PD). Although recent studies have suggested that mitochondrial association of αSyn may disrupt mitochondrial function, it is unclear what aggregation state of αSyn is most damaging...

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Bibliographic Details
Main Authors: Luth, Eric S., Stavrovskaya, Irina G., Bartels, Tim, Kristal, Bruce S., Selkoe, Dennis J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118111/
https://ncbi.nlm.nih.gov/pubmed/24942732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545749
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