Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

The nerve growth factor NGF has been shown to cause cell fate decisions toward either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT, or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to...

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Pubblicato in:Front Genet
Autori principali: Offermann, Barbara, Knauer, Steffen, Singh, Amit, Fernández-Cachón, María L., Klose, Martin, Kowar, Silke, Busch, Hauke, Boerries, Melanie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Genetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830832/
https://ncbi.nlm.nih.gov/pubmed/27148350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00044
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