Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

The nerve growth factor NGF has been shown to cause cell fate decisions toward either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT, or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to...

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Publicat a:Front Genet
Autors principals: Offermann, Barbara, Knauer, Steffen, Singh, Amit, Fernández-Cachón, María L., Klose, Martin, Kowar, Silke, Busch, Hauke, Boerries, Melanie
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830832/
https://ncbi.nlm.nih.gov/pubmed/27148350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00044
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