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Pan-cancer analysis of the extent and consequences of intra-tumor heterogeneity
Intra-tumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used EXPANDS and PyClone to detect clones >10% frequency within 1,165 exome sequences from TCGA tumors. 86% of tumors across 12 cancer types had at least two clones. ITH in nuclei morphology was associate...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830693/ https://ncbi.nlm.nih.gov/pubmed/26618723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3984 |
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