PLXNA4 is Associated with Alzheimer Disease and Modulates Tau Phosphorylation

OBJECTIVE: Much of the genetic basis for Alzheimer disease (AD) is unexplained. We sought to identify novel AD loci using a unique family-based approach that can detect robust associations with infrequent variants (minor allele frequency <0.10). METHODS: We conducted a genome-wide association stu...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Jun, Gyungah, Asai, Hirohide, Zeldich, Ella, Drapeau, Elodie, Chen, CiDi, Chung, Jaeyoon, Park, Jong-Ho, Kim, Sehwa, Haroutunian, Vahram, Foroud, Tatiana, Kuwano, Ryozo, Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Lunetta, Kathryn L., Kim, Jong-Won, Buxbaum, Joseph D., Mayeux, Richard, Ikezu, Tsuneya, Abraham, Carmela R., Farrer, Lindsay A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830273/
https://ncbi.nlm.nih.gov/pubmed/25043464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24219
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