A Systematic Review of Known Mechanisms of Hydroxyurea-induced Foetal Haemoglobin for Treatment of Sickle Cell Disease

AIMS: To report on molecular mechanisms of foetal haemoglobin (HbF) induction by hydroxyurea (HU) for the treatment of Sickle Cell Disease (SCD). STUDY DESIGN: Systematic review. RESULTS: Studies have provided consistent associations between genomic variations in HbF-promoting loci and variable HbF...

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Publié dans:Expert Rev Hematol
Auteurs principaux: Pule, Gift D., Mowla, Shaheen, Novitzky, Nicolas, Wiysonge, Charles S., Wonkam, Ambroise
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829639/
https://ncbi.nlm.nih.gov/pubmed/26327494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/17474086.2015.1078235
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