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Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11–48K and U11/U12–65K genes

Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for t...

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Vydáno v:RNA Biol
Hlavní autoři: Niemelä, Elina H, Verbeeren, Jens, Singha, Prosanta, Nurmi, Visa, Frilander, Mikko J
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829294/
https://ncbi.nlm.nih.gov/pubmed/26479860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1096489
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