Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo-Zenere, Esteban A., Maiwald, Franziska, Prousis, Kyriakos C., Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo R., Flohé, Leopold, Comini, Marcelo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829233/
https://ncbi.nlm.nih.gov/pubmed/27070550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004617
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