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Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione Synthetase
The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione and is an attractive new drug target for the development of trypanocidal and antileishmanial drugs, especially since the structural information of TryS from Leishmania major has b...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581523/ https://ncbi.nlm.nih.gov/pubmed/23451087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056788 |
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