Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo-Zenere, Esteban A., Maiwald, Franziska, Prousis, Kyriakos C., Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo R., Flohé, Leopold, Comini, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829233/
https://ncbi.nlm.nih.gov/pubmed/27070550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004617
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados