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New potential binding determinant for hERG channel inhibitors
Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K(+) current (I(Kr)) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828713/ https://ncbi.nlm.nih.gov/pubmed/27067805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24182 |
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